Assessment of Choroidal Thickness In Patients With Primary Angle Closure Glaucoma In Comparison to Non-glaucoma Subjects Using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography

Hamama Barry, Zeeshan Kamil, Afshan Ali, Muhammad Tanweer Hassan, Irfan Shafiq, Rida Azeem

Abstract

Objective 

To compare the choroidal thickness of non-glaucoma eyes subjects with the patients of primary angle closure glaucoma (PACG) using enhanced depth imaging spectral domain optical coherence tomography.

Study design

Comparative, cross sectional study.

Place & Duration of study

Layton Rahmatulla Benevolent Trust (LRBT) Hospital Karachi, from January 2024 to December 2024.

Methods

The patients with primary angle closure glaucoma (PACG) were compared with a group of subjects who had mild to moderate cataract. Enhanced depth imaging-optical coherence tomography (EDI-OCT) was used for the assessment of choroidal thickness. Data were entered into IBM SPSS version 27. The mean±SD were used to describe numeric variables, and percentages along with frequencies for the qualitative variables. Independent sample t-test was used to compare the means between the groups.

Results 

A total of 200 participants were enrolled. PACG patients were significantly older in age as compared to the non-glaucoma subjects (p<0.05). PACG patients had significantly higher intraocular pressure (IOP -19.36±7.21 mmHg - p<0.05), larger cup-to-disc (C:D ratio - 0.43±0.24 - p<0.05), shorter axial length (21.09±1.10mm - p<0.05), and thicker subfoveal choroid (281.53±8.40um, p<0.05). 

Conclusion

The findings of the study underscore structural differences in PACG patients and highlight the diagnostic value of enhanced depth imaging spectral domain OCT. The patients with PACG had thicker subfoveal choroid compared to the non-glaucoma subjects.

Key words

Angle closure glaucoma, Spectral domain OCT, Choroidal thickness, Intraocular pressure, Cup-to-disc ratio.