Diagnostic Accuracy of C- Reactive Protein In Predicting Mortality Among Patients With Acute Pancreatitis

Fatima Yousuf, Syeda Sarah Kazmi, Syed Ali Haider, Muhammad Zubair, Sidrah Masoom, Aymen Sattar

Abstract

Objective 

To find out the diagnostic accuracy of serum C- reactive protein (CRP) in predicting the mortality in patients of acute pancreatitis patients within 28-days of admission to a hospital.

Study design

Cross-sectional observational study.

Place & Duration of study

Department of Surgery, Dr. Ruth K.M. Pfau Civil Hospital Karachi, from April 2022 to September 2022.

Methods

All patients with the diagnosis of acute pancreatitis of any severity, were included. The serum CRP levels were checked at 48-hours after admission. The sensitivity, specificity, positive and negative predictive values (PPV, NPV) and diagnostic accuracy of the measured CRP level were assessed in predicting the mortality. Data were entered into the SPSS version 21. Chi square / Fisher exact tests were used post-stratification to find out the significance level according to the age, gender and duration of hospital stay

Results

A total 150 diagnosed patients of acute pancreatitis were enrolled. The mean age of the patients was 40.21±11.07 years. There were 106 (70.7%) female and 44 (29.3%) male patients. The hospital stay on an average was 6.03±2.19 days (from 4 to 25-days). The overall mortality among the study population was 15.3% (n=23). The overall mean CRP level among the study population was 150.00±69.89 mg/dl. The diagnostic accuracy of elevated serum CRP was 58.7% in predicting 28-days mortality in acute pancreatitis.

Conclusion

CRP levels determined at 48-hours after admission can be helpful in determining the risk of mortality in patients with acute pancreatitis.

Key words

Acute pancreatitis, Diagnostic accuracy, C – reactive protein, Mortality, Multiple organ failure.