Tranexamic Acid For Seroma Reduction
Surrendar Dawani, Hassan Ahmed, Salman Jafferi, Shahid Rasul
Abstract
Objective
To compare the safety and effectiveness of tranexamic acid in reducing postoperative seroma formation in ventral hernia repair.
Study design
Comparative study.
Place & Duration of study
Department of Surgery Ward 21 Unit IV, Jinnah Postgraduate Medical Centre (JPMC) Karachi, from July 2019 to February 2020.
Methodology
Patients with ventral abdominal hernia were included in the study. Study was approved by institution review board. A detailed history and clinical examination were done and routine biochemical investigations requested. Patients were operated after informed consent. Standard Onlay mesh repair was performed. Patients were divided into study and control groups. Tranexamic acid was given postoperatively to study group till 5th postoperative day (POD). Drains were placed under the skin flaps to record the volume of seroma after surgery. The outcome was assessed by comparing the volume of seroma postoperatively in both the groups.
Results
Sixty patients were enrolled with female to male ratio of 3:1. Mean age of the patients was 41.67±9.76 year. Twenty-one (35%) patients were <35 years of age. Mean volume of seroma formation in postoperative period in study group was 74.00+35.92 ml versus 130.00±055.96 ml in control group, which was highly significant (p= 0.001). Patients were stratified according to age and gender which showed no significant difference in relation to these variables.
Conclusion
Tranexamic acid is effective in reducing the volume of seroma postoperatively in patients with ventral hernia repair.
Key words
Tranexamic acid, Fibrinolysis, Plasminogen, Seroma.
