Role of Tranexamic Acid In Reducing Blood Loss After Cesarean Section

Sumaira Akbar, Nasreen Fatima

Abstract

Objective

To evaluate the effectiveness of tranexamic acid in reducing blood loss following cesarean section.

Study design

Descriptive cross-sectional study.

Place & Duration of study

Department of Obstetrics & Gynaecology, Jinnah Postgraduate Medical Center (JPMC) Karachi, from June 2019 to December 2019.

Methodology

Women irrespective of age and parity with singleton pregnancy, cephalic presentation, who underwent lower segment cesarean section, were selected. Women who had major medical illness like renal failure, liver failure, and severe pre-eclampsia, required blood transfusion due to anemia, multiple pregnancy, coagulation disorders and polyhydramnios were excluded. One-gm (10ml) tranexamic acid (TXA) injection diluted in 20 ml of 5% dextrose was given intravenously  20 minutes before proceeding to skin incision. Patients observed from surgery till 24 hours postoperatively and blood loss calculated.

Results

A total of 130 women between 18 year - 30year were include. The mean age of study subjects was 24.75±2.41year. Of the total 79 (59.85%) women belonged to 18 year - 25year age group. The mean gestational age was 38.84±1.23 weeks. In 51(40.15%) patients tranexamic acid was found effective in reducing blood loss following cesarean section.

Conclusion

In large number of patients effectiveness of tranexamic acid was noted in lowering blood loss following cesarean section.

Key words

Cesarean section, Tranexamic acid, Efficacy, Postpartum hemorrhage.