Helicobacter Pylori Infection With Cholelitihiasis

Shahida Parveen Afridi, Naveed Ali Khan, Abdul Khalique, Fizzah Khalid

  • Shahida Parveen Afridi Department of General Surgery Dow University of Health Sciences DIMC Karachi



To find out the association of Helicobacter pylori infection with cholelithiasis.

Study design

Descriptive case series.

Place & Duration of study

Dow International University Hospital Ojha Campus, Dow University of Health Sciences Karachi, from January  2016 to December 2018.


Patients with symptomatic gall stones were included. Ultrasound abdomen performed in all the patients to confirm the presence of gall stones. Blood sample was used to detect the H. pylori antibody and stool for H. pylori antigen to confirm the presence or absence of H. pylori infection.


A total 187 patients were included. There were 31(16.5%) male and 156 (83.42%) female patients with mean age of 41.31+11.47 year. Helicobacter pylori antibody was positive in 120 (64.17%) patients with p value 0.02 and stool antigen tests were positive in 65 (34.75%) patients with p value 0.03. Helicobacter pylori antibody and stool antigen, both tests were negative in 12 (6.41%) patients. Histopathology finding revealed chronic cholecystitis in 155 (82.88%) patients and chronic cholecystitis with cholesterolosis in 32 (17.11%) patients.


Strong association of Helicobacter pylori infection was found with cholelithiasis.

Key words

H. pylori, Cholelithiasis, Acid peptic disease, Cholecystectomy.