Effect of Mitomycin C In Reducing External Dacryocystorhinostomy Failure

Qirat Qurban, Zeeshan Kamil, Khalid Mahmood

  • Qirat Qurban Khalid Eye Clinic Karachi



To find out effectiveness of mitomycin C soaked gauze during external dacryocystorhinostomy surgery in reducing the failure rate of the procedure.

Study design

Quasi experimental Study.

Place & Duration of study

Khalid Eye Clinic Karachi, from November 2018 to January 2020.


Patients were evaluated with regurgitation test for site and severity of obstruction. Lacrimal sac syringing was performed for documenting patency of lacrimal system. Bowman’s probe was used where distal obstruction was suspected. External dacryocystorhinostomy surgery was performed with intra operative use of MMC 0.02% soaked gauze piece passed through the anastomosed dacryocystorhinostomy flaps and the osteotomy site for 2 minutes. Silicone tube was passed through the ostium into the nasal cavity and skin was sutured. Silicon tube was removed six months after the surgery.  Patients were followed up to nine months.


Fifty patients of both genders were recruited. Age of the study subjects was from 20 year to 40 year with the mean age of 31.3 ± 5.3 year. Forty-seven (94%) patients had a patent postoperative nasolacrimal system which was proven by nasolacrimal syringing test. Three (6%) patients complained of watering and discharge and required revision surgeries.


Use of mitomycin C during external dacryocystorhinostomy surgery reduced the postoperative surgical failure.

Key words

Mitomycin C, External dacryocystorhinostomy, Dacryocystitis.