Assessment of Diagnostic Accuracy of the Risk of Malignancy Index in Ovarian Masses with Histopathology as the Gold Standard

Nasreen Fatima, Hira Raza

Abstract

Objective

To ascertain the diagnostic accuracy of Risk of Malignancy Index (RMI) for diagnosing malignant ovarian masses taking histopathology findings as gold standard.

Study design

Cross sectional validation study.

Place & Duration of study

Department of Obstetrics & Gynecology, Jinnah Postgraduate Medical Centre (JPMC) Karachi, from May 2022 to November 2022.

Methods

Women between 20-years to 60-years of age with ovarian masses were enrolled by non-probability consecutive sampling methods. Demographic data like age, duration of the lesion, size of the mass were noted. Risk of malignancy index was calculated in each patient and malignant ovarian mass were identified. Surgery was then performed and specimen sent for histopathology to document the nature of the ovarian mass. RMI results were compared with histopathology findings.

Results

A total of 141 women were included. The mean age of the patients was 43.22±8.39 years and mean duration of the disease 6.55±1.48 months. Majority of the women (n=71-51.06%) presented with < 6-months duration of disease. In 91 (64.54%) women size of the lesion was < 3 cm. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of RMI for diagnosing malignant ovarian masses taking histopathology findings as gold standard were 88.10%, 91.23%, 93.67%, 83.87% and 89.36% respectively. 

Conclusion

The diagnostic accuracy of RMI was high and helped in making preoperative diagnosis for planning treatment and counseling of the patients.

Key words

Ovarian tumor, Risk of malignancy index, Diagnostic accuracy, Malignant tumors.